Prague, is situated on the Vltava River in central Bohemia. It is the capital and largest city of the Czech Republic. The city proper is home to about 1.3 million people, while its metropolitan area is estimated to have a population of over 2.3 million. It has been a political, cultural and economic center of Europe and particularly central Europe for the over 1,100 years of its existence. For centuries, during the Gothic and Renaissance eras, Prague was the permanent seat of two Holy Roman Emperors and thus was also the capital of the Holy Roman Empire. The city played roles in the Protestant Reformation, the Thirty Years' War, and in 20th-century history, both during the two World Wars and during the post-war Communist era. 

Strasbourg is the capital and principal city of the Alsace region in north-eastern France and is the official seat of the European Parliament. Located close to the border with Germany, it is the capital of the Bas-Rhin department. In 2006, the city proper had 272,975 inhabitants and its urban community 467,375 inhabitants. With 638,670 inhabitants in 2006, Strasbourg's metropolitan area ("aire urbaine") (only the part of the metropolitan area on French territory) is the ninth largest in France. The transnational Eurodistrict Strasbourg-Ortenau has a population of 884,988 inhabitants.

Heidelberg is a German city situated in the south-west of the country. The fifth largest city of the German State of Baden-Württemberg after Stuttgart, Mannheim, Karlsruhe and Freiburg im Breisgau, Heidelberg is part of a densely populated region known as the Rhine-Neckar Metropolitan Region. As of 2009, over 145,000 people live within the city's area. Heidelberg lies on the River Neckar in a steep valley in the Odenwald. Heidelberg — having been a former residence of the Electoral Palatinate in the past — is the seat of the University of Heidelberg, which is well-known far beyond its and Germany's borders. Heidelberg is also a popular tourist destination due to its romantic and picturesque cityscape's character, including the Heidelberg Castle and the baroque style Old Town. The US Army has had a military base in Heidelberg since 1951.

Basel is one of the important cities of Switzerland. One of Switzerland's underrated tourist destinations, Basel has a beautiful medieval old town centre, a vibrant Carnival, and several world class art museums built by architects like Renzo Piano, Mario Botta and Herzog & De Meuron. Basel is also rich in architecture old and new, with a Romanesque Münster (cathedral), a Renaissance Rathaus (town hall), and various examples of high quality contemporary architecture, including more buildings by Herzog & De Meuron, Richard Meier, Diener & Diener, and various others. Located in the Dreiländereck (three countries' corner), Basel is a gateway to the Swiss Jura mountains and nearby cities of Zürich and Lucerne, as well as the neighbouring French region of Alsace and the German Black Forest.

Nuremberg is a city on the river Pegnitz and the Rhine–Main–Danube Canal in the German state of Bavaria, in the administrative region of Middle Franconia. When people think of Nuremberg, they usually think of gingerbread, toys, Christmas, the Reich Party Rally Grounds, or the Nuremberg Trials. But the old town of Nuremberg is much more than this and indeed Nuremberg probably comes closest to many tourists' expectations of a typical German city: On the one hand one can find half-timbered houses, gothic churches within a medival city wall in the shadow of the towering imperial castle, which was one of the most important residences of the emporers of the Holy Roman Empire.