San Francisco, officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.5 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km2) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km2). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

Ensenada is a coastal city in Mexico, the third-largest in Baja California. Lying 125 kilometres (78 mi) south of San Diego on the Baja California Peninsula, it is locally referred to as La Cenicienta del Pacífico, "The Cinderellaof the Pacific''. One of the first settlements founded in the Californias, Ensenada has emerged as a cruise ship destination, aerospace center, and there is a nearby region to the north east where wine grapes are grown.  Situated on the coastline of Bahía de Todos Santos—an inlet of the Pacific Ocean on the peninsula's Gold Coast—the Port of Ensenada is an important commercial, fishing, and tourist port. The city is home to a navy base, army base, and Ensenada Airport, a military airfield which doubles as an airport of entry into Mexico.

Santa Barbara is the county seat of Santa Barbara County, California, United States. Located on an east-west trending section of coastline, the longest such section on the West Coast of the United States, the city lies between the steeply-rising Santa Ynez Mountains and the Pacific Ocean. Santa Barbara's climate is often described as Mediterranean, and the city is sometimes referred to as the "American Riviera." In addition to being a popular tourist and resort destination, the city economy includes a large service sector, education, technology, health care, finance, agriculture, manufacturing, and local government. In 2004, the service sector accounted for fully 35% of local employment. Education in particular is well represented, with five institutions of higher learning on the south coast (the University of California, Santa Barbara, Santa Barbara City College, Westmont College, Antioch University, and the Brooks Institute of Photography).

Los Angeles, Spanish for "The Angels", is the most populous city in California and the second most populous in the United States, with a population of 4.06 million on a land area of 498.3 square miles (1,290.6 km2). It is the focal point of the larger Los Angeles-Long Beach Riverside  combined statistical area, which contains nearly 17.8 million people. This makes it the 12th most populous metropolitan area in the world. Los Angeles is also the seat of Los Angeles County, the most populated and one of the most multicultural counties in the United States. The city's inhabitants are referred to as "Angelenos".